Tracing back to one of the origins of immune evasion in pancreatic cancer

Cancer Cell. 2022 Jun 13;40(6):595-597. doi: 10.1016/j.ccell.2022.05.002. Epub 2022 May 26.

Abstract

In this issue of Cancer Cell, Huang et al. identify the origin and function of a subset of pancreatic cancer-associated fibroblasts. This work further highlights the power of lineage-tracing models for dissecting the tumor microenvironment in pancreatic cancer and provides new knowledge toward the development of novel therapeutic strategies.

Publication types

  • Comment

MeSH terms

  • Cancer-Associated Fibroblasts* / pathology
  • Humans
  • Immune Evasion
  • Pancreatic Neoplasms* / pathology
  • Tumor Microenvironment