RF coil design for accurate parallel imaging on ¹³ C MRSI using ²³ Na sensitivity profiles

Purpose: To develop a coil-based method to obtain accurate sensitivity profiles in ¹³ C MRI at 3T from the endogenous ²³ Na. An eight-channel array is designed for ¹³ C MR acquisitions. As application examples, the array is used for two-fold accelerated acquisitions of both hyperpolarized ¹³ C metabolic imaging of pig kidneys and the human brain.

Methods: A flexible coil array was tuned optimally for ¹³ C at 3T (32.1 MHz), with the coil coupling coefficients matched to be nearly identical at the resonance frequency of ²³ Na (33.8 MHz). This is done by enforcing a high decoupling (obtained through highly mismatched preamplifiers) and adjusting the coupling frequency response. The SNR performance is compared to reference coils.

Results: The measured sensitivity profiles on a phantom showed high spatial similarity for ¹³ C and ²³ Na resonances, with average noise correlation of 9 and 11%, respectively. For acceleration factors 2, 3, and 4, the obtained maximum g-factors were 1.0, 1.1, and 2.6, respectively. The ²³ Na profiles obtained in vivo could be used successfully to perform two-fold acceleration of hyperpolarized ¹³ C 3D acquisitions of both pig kidneys and a healthy human brain.

Conclusion: A receive array has been developed in such a way that the ¹³ C sensitivity profiles could be accurately obtained from measurements at the ²³ Na frequency. This technique facilitates accelerated acquisitions for hyperpolarized ¹³ C imaging. The SNR performance obtained at the ¹³ C frequency, compares well to other state-of-the-art coils for the same purpose, showing slightly better superficial and central SNR.