COVID-19 Pathogenesis and Clinical Manifestations

R Alfonso Hernandez Acosta; Zerelda Esquer Garrigos; Jasmine R Marcelin; Prakhar Vijayvargiya

doi:10.1016/j.idc.2022.01.003

COVID-19 Pathogenesis and Clinical Manifestations

Infect Dis Clin North Am. 2022 Jun;36(2):231-249. doi: 10.1016/j.idc.2022.01.003. Epub 2022 Feb 1.

Authors

R Alfonso Hernandez Acosta¹, Zerelda Esquer Garrigos², Jasmine R Marcelin³, Prakhar Vijayvargiya⁴

Affiliations

¹ Department of Internal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA.
² Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, USA.
³ Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
⁴ Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, USA. Electronic address: [email protected].

Abstract

In this review, we summarize the current knowledge about the virology, the host-pathogen interactions and pathogenesis of coronavirus disease 2019 in humans. We also describe the various clinical presentations of the disease including respiratory system and extrapulmonary manifestations.

Keywords: COVID-19; Clinical manifestations; Pathogenesis; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19*
Host-Pathogen Interactions
Humans