An early warning system for emerging SARS-CoV-2 variants

Lorenzo Subissi; Anne von Gottberg; Lipi Thukral; Nathalie Worp; Bas B Oude Munnink; Surabhi Rathore; Laith J Abu-Raddad; Ximena Aguilera; Erik Alm; Brett N Archer; Homa Attar Cohen; Amal Barakat; Wendy S Barclay; Jinal N Bhiman; Leon Caly; Meera Chand; Mark Chen; Ann Cullinane; Tulio de Oliveira; Christian Drosten; Julian Druce; Paul Effler; Ihab El Masry; Adama Faye; Simani Gaseitsiwe; Elodie Ghedin; Rebecca Grant; Bart L Haagmans; Belinda L Herring; Shilpa S Iyer; Zyleen Kassamali; Manish Kakkar; Rebecca J Kondor; Juliana A Leite; Yee-Sin Leo; Gabriel M Leung; Marco Marklewitz; Sikhulile Moyo; Jairo Mendez-Rico; Nada M Melhem; Vincent Munster; Karen Nahapetyan; Djin-Ye Oh; Boris I Pavlin; Thomas P Peacock; Malik Peiris; Zhibin Peng; Leo L M Poon; Andrew Rambaut; Jilian Sacks; Yinzhong Shen; Marilda M Siqueira; Sofonias K Tessema; Erik M Volz; Volker Thiel; Sylvie van der Werf; Sylvie Briand; Mark D Perkins; Maria D Van Kerkhove; Marion P G Koopmans; Anurag Agrawal

doi:10.1038/s41591-022-01836-w

An early warning system for emerging SARS-CoV-2 variants

Nat Med. 2022 Jun;28(6):1110-1115. doi: 10.1038/s41591-022-01836-w.

Authors

Lorenzo Subissi¹, Anne von Gottberg^{2

3}, Lipi Thukral⁴, Nathalie Worp^{5

6}, Bas B Oude Munnink^{5

6}, Surabhi Rathore⁴, Laith J Abu-Raddad⁷, Ximena Aguilera⁸, Erik Alm⁹, Brett N Archer¹, Homa Attar Cohen¹, Amal Barakat¹⁰, Wendy S Barclay¹¹, Jinal N Bhiman^{2

3}, Leon Caly¹², Meera Chand¹³, Mark Chen¹⁴, Ann Cullinane¹⁵, Tulio de Oliveira¹⁶, Christian Drosten¹⁷, Julian Druce⁸, Paul Effler¹⁸, Ihab El Masry¹⁹, Adama Faye²⁰, Simani Gaseitsiwe^{21

22}, Elodie Ghedin²³, Rebecca Grant¹, Bart L Haagmans^{5

6}, Belinda L Herring²⁴, Shilpa S Iyer²⁵, Zyleen Kassamali¹, Manish Kakkar²⁶, Rebecca J Kondor²⁷, Juliana A Leite²⁸, Yee-Sin Leo¹⁴, Gabriel M Leung²⁹, Marco Marklewitz³⁰, Sikhulile Moyo^{21

22}, Jairo Mendez-Rico²⁸, Nada M Melhem³¹, Vincent Munster³², Karen Nahapetyan³⁰, Djin-Ye Oh³³, Boris I Pavlin¹, Thomas P Peacock^{11

13}, Malik Peiris²⁹, Zhibin Peng³⁴, Leo L M Poon²⁹, Andrew Rambaut³⁵, Jilian Sacks¹, Yinzhong Shen³⁶, Marilda M Siqueira³⁷, Sofonias K Tessema³⁸, Erik M Volz¹¹, Volker Thiel^{39

40}, Sylvie van der Werf⁴¹, Sylvie Briand¹, Mark D Perkins¹, Maria D Van Kerkhove⁴², Marion P G Koopmans^{5

6}, Anurag Agrawal⁴³

Affiliations

¹ World Health Organization, Geneva, Switzerland.
² National Institute for Communicable Diseases, Johannesburg, South Africa.
³ School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁴ CSIR Institute of Genomics and Integrative Biology, Delhi, India.
⁵ Erasmus Medical Centre, Rotterdam, the Netherlands.
⁶ Pandemic and Disaster Preparedness Research Centre, Rotterdam/Delft, the Netherlands.
⁷ Weill Cornell Medicine - Qatar of Cornell University, Doha, Qatar.
⁸ Epidemiology and Health Policy Centre, Universidad del Desarollo, Santiago, Chile.
⁹ European Centre for Disease Prevention and Control, Stockholm, Sweden.
¹⁰ World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt.
¹¹ Imperial College London, London, UK.
¹² Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia.
¹³ UK Health Security Agency, London, UK.
¹⁴ National Centre for Infectious Diseases, Singapore, Singapore.
¹⁵ World Organisation for Animal Health, Paris, France.
¹⁶ Centre for Epidemic Response and Innovation, Stellenbosch University, Stellenbosch, South Africa.
¹⁷ Charité Medical Center, Berlin, Germany.
¹⁸ University of Western Australia, Perth, Western Australia, Australia.
¹⁹ Food and Agriculture Organization, Rome, Italy.
²⁰ Institut de Santé et Développement, Université Cheikh Anta Diop, Dakar, Senegal.
²¹ Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
²² Harvard T.H Chan School of Public Health, Department of Immunology & Infectious Diseases, Boston, MA, USA.
²³ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
²⁴ World Health Organization Regional Office for Africa, Brazzaville, Republic of Congo.
²⁵ World Health Organization Regional Office for Western Pacific, Manila, The Philippines.
²⁶ World Health Organization Regional Office for South-East Asia, New Delhi, India.
²⁷ United States Centers for Disease Control and Prevention, Atlanta, GA, USA.
²⁸ World Health Organization Regional Office for the Americas, Washington, DC, USA.
²⁹ School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, The People's Republic of China.
³⁰ World Health Organization Regional Office for Europe, Copenhagen, Denmark.
³¹ American University of Beirut, Beirut, Lebanon.
³² National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
³³ Robert Koch Institute, Berlin, Germany.
³⁴ Chinese Center for Disease Control and Prevention, Beijing, The People's Republic of China.
³⁵ University of Edinburgh, Edinburgh, UK.
³⁶ Shanghai Public Health Clinical Center, Fudan University, Shanghai, The People's Republic of China.
³⁷ Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
³⁸ Africa Centers for Disease Control and Prevention, Addis Ababa, Ethiopia.
³⁹ Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland.
⁴⁰ Institute of Virology and Immunology, Mittelhäusern and Bern, Switzerland.
⁴¹ Institut Pasteur, Université Paris Cité, Paris, France.
⁴² World Health Organization, Geneva, Switzerland. [email protected].
⁴³ Trivedi School of Biosciences, Ashoka University, Sonipat, India.

Abstract

Global sequencing and surveillance capacity for SARS-CoV-2 must be strengthened and combined with multidisciplinary studies of infectivity, virulence, and immune escape, in order to track the unpredictable evolution of the ongoing COVID-19 pandemic.

An early warning system for emerging SARS-CoV-2 variants

Authors

Affiliations

Abstract

MeSH terms

Supplementary concepts

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