Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia

Jiangchao Wu; Jinyuan Song; Xianghong Yin; Jianghui Tang; Junlei Zhang; Xun Wang; Yongtao Ji; Yaxing Zhao; Dong Chen; Jianpeng Sheng; Xueli Bai; Tingbo Liang

doi:10.31083/j.fbl2705145

Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia

Front Biosci (Landmark Ed). 2022 May 6;27(5):145. doi: 10.31083/j.fbl2705145.

Authors

Jiangchao Wu^{1

2

3}, Jinyuan Song^{1

2

3}, Xianghong Yin⁴, Jianghui Tang^{1

2

3}, Junlei Zhang^{1

2

3}, Xun Wang^{1

2

3}, Yongtao Ji^{1

2

3}, Yaxing Zhao^{1

2

3}, Dong Chen^{5

6}, Jianpeng Sheng^{1

2

3}, Xueli Bai^{1

2

3}, Tingbo Liang^{1

2

3}

Affiliations

¹ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 310000 Hangzhou, Zhejiang, China.
² Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, 310000 Hangzhou, Zhejiang, China.
³ Zhejiang University Cancer Center, Zhejiang University, 310000 Hangzhou, Zhejiang, China.
⁴ Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, 310000 Hangzhou, Zhejiang, China.
⁵ Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, 310000 Hangzhou, Zhejiang, China.
⁶ College of Energy Engineering and State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University, 310027 Hangzhou, Zhejiang, China.

PMID: 35638412
DOI: 10.31083/j.fbl2705145

Abstract

Hypoxia is a typical characteristic of most solid malignancies, which has multiple effects on malignant phenotypes and biological behaviors of tumors including epithelial-mesenchymal-transition (EMT), invasion, migration, metastasis, autophagy, stem cell maintenance, pathological angiogenesis, drug resistance, and immunosuppression. Rcentlyumoand reversing the tumor hypoxic environment via nanotechnology has emerged as a novel therapeutic approach for the treatment of malignancies. The main strategies related to nanotechnology to alleviate or ameliorate hypoxic environment are as follows: (1) Bringing external oxygen to tumor hypoxic microenvironment; (2) Generating oxygen based on nanotechnology in situ; (3) Regulating the structure of the tumor microenvironment; (4) Decreasing oxygen consumption in the tumor microenvironment. In this review, we will discuss these nanotechnologies in detail.

Keywords: hypoxia; metal-organic frameworks; nanotechnology; photodynamic therapy; tumor microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Hypoxia / therapy
Nanotechnology
Neoplasms* / genetics
Oxygen
Tumor Microenvironment*

Substances

Oxygen