Regulating gene expression through control of transcription factor multivalent interactions

Mol Cell. 2022 Jun 2;82(11):1974-1975. doi: 10.1016/j.molcel.2022.05.015.

Authors

Benjamin T Donovan¹, Daniel R Larson²

Affiliations

¹ Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
² Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: [email protected].

PMID: 35659322
DOI: 10.1016/j.molcel.2022.05.015

Abstract

Chong et al. (2022) show how the propensity of transcription factors (TFs) to associate into hubs must be finely regulated for optimal transcription.

Published by Elsevier Inc.

Publication types

Research Support, N.I.H., Intramural
Comment

MeSH terms

Gene Expression
Gene Expression Regulation*
Transcription Factors* / genetics
Transcription Factors* / metabolism

Substances

Transcription Factors