Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom

Beraldo-Neto Emidio; Lebrun Ivo; Nencioni Ana Leonor Abrahao

doi:10.1016/j.toxcx.2022.100126

Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom

Toxicon X. 2022 May 27:15:100126. doi: 10.1016/j.toxcx.2022.100126. eCollection 2022 Sep.

Authors

Beraldo-Neto Emidio^{1

2}, Lebrun Ivo², Nencioni Ana Leonor Abrahao³

Affiliations

¹ Post-Graduation Program in Science - Toxinology of Butantan Institute, Av. Dr. Vital Brazil 1500, São Paulo, 05503-900, Brazil.
² Laboratory of Biochemistry and Biophysics, Butantan Institute, Av. Dr. Vital Brazil 1500, São Paulo, 05503-900, Brazil.
³ Laboratory of Pharmacology, Butantan Institute, Av. Dr. Vital Brazil 1500, São Paulo, 05503-900, Brazil.

Abstract

Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter other neurotransmitters. Thus, dopaminergic system seems to be partially responsible for the convulsive process. Specific action on particular neurotransmitter can make this toxin a useful tool to better understand the functioning of the system.

Keywords: Dopaminergic system; Hippocampus; Neurotoxin; Neurotransmitters; Tityus bahiensis.