Monoclonal antibodies for mild-to-moderate COVID-19 in multiple sclerosis: A case series

J Neurol Sci. 2022 Aug 15:439:120306. doi: 10.1016/j.jns.2022.120306. Epub 2022 Jun 2.

Abstract

We reported on five people with MS, using immunodepleting disease modifying treatments (anti-CD20 monoclonal antibodies and sphingosine-one-phosphate modulators) and with reduced COVID-19 vaccine response, who had mild-to-moderate symptomatic COVID-19, and were treated with anti-SARS-CoV-2 monoclonal antibodies. In particular, we showed the possibility to use monoclonal antibodies to speed-up recovery from COVID-19 in MS, in the absence of any COVID-19 residuals or MS changes (e.g., relapses or disability).

Keywords: COVID-19; Monoclonal antibodies; Multiple sclerosis; Treatment.

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Viral
  • COVID-19 Vaccines
  • COVID-19*
  • Humans
  • Multiple Sclerosis* / complications
  • Multiple Sclerosis* / drug therapy

Substances

  • Antibodies, Monoclonal
  • Antibodies, Viral
  • COVID-19 Vaccines