Spray dried hydroxyapatite-based supraparticles with uniform and controllable size and morphology

This work aims to prepare uniform spray dried hydroxyapatite-based (SD HAP-based) supraparticles with controllable morphology via micro-fluidic spray drying. Sodium polyacrylate (PAAS) and sodium chloride (NaCl) were used to prepare the precursor suspensions by regulating the inter-particle repulsive forces and electrostatic shielding effect, respectively. The particle size (D50) and zeta potential of the suspension were highly associated with the mass ratio of HAP to PAAS (m_H/m_P) and the NaCl concentration (C_NaCl), which further had significant effect on the permeability (k) of the droplet shell formed during spray drying and ultimately the supraparticle morphology. D50 ˂ 2 µm and absolute zeta potential ˃ 20 mV, obtained when m_H/m_P ˂ 100 under low C_NaCl, rendered ultralow k and consequently deformed supraparticles; Whereas D50 ˃ 2 µm and absolute zeta potential ˂ 20 mV, achieved by decreasing PAAS amount, i.e. m_H/m_P ≥ 100 or improving C_NaCl to efficiently screen surface net charge of HAP, high k and spherical supraparticles were thus preferentially formed.