Atropisomerism in a polyglutamate-based thermoresponsive alignment medium

Dominic S Schirra; Philipp Götz; Matthias Lehmann; Christina M Thiele

doi:10.1039/d2cc01982e

Atropisomerism in a polyglutamate-based thermoresponsive alignment medium

Chem Commun (Camb). 2022 Jul 5;58(54):7511-7514. doi: 10.1039/d2cc01982e.

Authors

Dominic S Schirra¹, Philipp Götz¹, Matthias Lehmann², Christina M Thiele¹

Affiliations

¹ Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry, Research and Laboratory Center M3, Technical University of Darmstadt, Alarich-Weiss-Str. 16, 64287 Darmstadt, Germany. [email protected].
² Institute for Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

PMID: 35708488
DOI: 10.1039/d2cc01982e

Abstract

Structure elucidation via residual dipolar couplings (RDCs) relies on alignment media. We report on lyotropic liquid crystals (LLCs) of poly-γ-p-biphenyl(2'-methoxy-2-methyl)methyl-L-glutamate (PBPM³LG). Temperature dependent atropisomerism within the biphenyl group enables the acquisition of multiple RDC-datasets within one sample.

MeSH terms

Liquid Crystals* / chemistry
Nuclear Magnetic Resonance, Biomolecular
Polyglutamic Acid* / chemistry
Temperature

Substances

Polyglutamic Acid