Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment

Cancer Res. 2022 Jul 18;82(14):2593-2609. doi: 10.1158/0008-5472.CAN-21-3506.

Abstract

Comprehensive single-cell proteomics analyses of lung adenocarcinoma progression reveal the role of tumor-associated macrophages in resistance to PD-1 blockade therapy. See related commentary by Lee et al., p. 2515.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adenocarcinoma of Lung*
  • Adenocarcinoma* / pathology
  • Humans
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / pathology
  • Macrophages
  • Tumor Microenvironment