Incidence of Intussusception in Bamako, Mali, Before and After the Introduction of Rotavirus Vaccine

Anna Roose; Adama Mamby Keita; Milagritos D Tapia; Samba O Sow; T Christopher Mast; Karen L Kotloff

doi:10.1093/jpids/piac044

Incidence of Intussusception in Bamako, Mali, Before and After the Introduction of Rotavirus Vaccine

J Pediatric Infect Dis Soc. 2022 Sep 29;11(9):404-407. doi: 10.1093/jpids/piac044.

Authors

Anna Roose¹, Adama Mamby Keita², Milagritos D Tapia^{1

3}, Samba O Sow², T Christopher Mast⁴, Karen L Kotloff^{1

3}

Affiliations

¹ Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
² Centre for Vaccine Development, Bamako, Mali.
³ Department of Pediatrics and Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
⁴ Merck & Co., Kenilworth, New Jersey, USA.

Abstract

Pentavalent rotavirus vaccine has been associated with a small increase in intussusception, but pre- and post-introduction data are lacking in many low-resource settings. Using chart review and prospective surveillance data, intussusception incidence was estimated in Bamako, Mali. The mean annual intussusception incidence post-introduction was not significantly different from that of pre-introduction.

Keywords: Mali; RotaTeq; immunization; intussusceptions; post-marketing surveillance.

MeSH terms

Humans
Incidence
Infant
Intussusception* / epidemiology
Intussusception* / etiology
Mali / epidemiology
Prospective Studies
Rotavirus Infections* / epidemiology
Rotavirus Infections* / prevention & control
Rotavirus Vaccines* / adverse effects
Rotavirus*
Vaccines, Combined

Substances

Rotavirus Vaccines
Vaccines, Combined

Grants and funding

Merck & Co, Inc