Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers

Roos S G Sablerolles; Wim J R Rietdijk; Abraham Goorhuis; Douwe F Postma; Leo G Visser; Katharina S Schmitz; Daryl Geers; Susanne Bogers; Eva van Haren; Marion P G Koopmans; Virgil A S H Dalm; Neeltje A Kootstra; Anke L W Huckriede; Renate Akkerman; Martin Beukema; Melvin Lafeber; Debbie van Baarle; Rory D de Vries; P Hugo M van der Kuy; Corine H GeurtsvanKessel; SWITCH Research Group

doi:10.1093/cid/ciac495

Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers

Clin Infect Dis. 2023 Feb 8;76(3):e533-e536. doi: 10.1093/cid/ciac495.

Authors

Roos S G Sablerolles^{1

2}, Wim J R Rietdijk², Abraham Goorhuis^{3

4}, Douwe F Postma⁵, Leo G Visser⁶, Katharina S Schmitz⁷, Daryl Geers⁷, Susanne Bogers⁷, Eva van Haren², Marion P G Koopmans⁷, Virgil A S H Dalm⁸, Neeltje A Kootstra⁹, Anke L W Huckriede¹⁰, Renate Akkerman¹⁰, Martin Beukema¹⁰, Melvin Lafeber¹, Debbie van Baarle^{10

11}, Rory D de Vries⁷, P Hugo M van der Kuy², Corine H GeurtsvanKessel⁷; SWITCH Research Group

Affiliations

¹ Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
² Department of Hospital Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands.
³ Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
⁴ Infection & Immunity, Amsterdam Public Health, University of Amsterdam, Amsterdam, The Netherlands.
⁵ Department of Internal Medicine and Infectious Diseases, University Medical Center Groningen, Groningen, The Netherlands.
⁶ Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
⁷ Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
⁸ Department of Internal Medicine, Division of Allergy & Clinical Immunology and Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.
⁹ Department of Experimental Immunology, Amsterdam University Medical Centers, Amsterdam Infection and Immunity Institute, University of Amsterdam, Amsterdam, The Netherlands.
¹⁰ Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
¹¹ Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Abstract

The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

Keywords: Ad26.COV2.S; SARS-CoV-2; waning immunity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ad26COVS1*
Antibodies, Neutralizing
Antibodies, Viral
COVID-19*
Health Personnel
Humans
Immunity
SARS-CoV-2

Substances

Ad26COVS1
Antibodies, Neutralizing
Antibodies, Viral

Supplementary concepts

SARS-CoV-2 variants

Grants and funding

U01 CK000632/CK/NCEZID CDC HHS/United States