Do genetic factors contribute to sex-specific differences in resilience to amyloid pathology?

Colin Groot; Henne Holstege; Rik Ossenkoppele

doi:10.1093/brain/awac216

Do genetic factors contribute to sex-specific differences in resilience to amyloid pathology?

Brain. 2022 Jul 29;145(7):2239-2241. doi: 10.1093/brain/awac216.

Authors

Colin Groot^{1

2

3}, Henne Holstege^{1

2

4}, Rik Ossenkoppele^{1

2

3}

Affiliations

¹ Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
² Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
³ Lund University, Clinical Memory Research Unit, Lund, Sweden.
⁴ Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.

Abstract

This scientific commentary refers to ‘Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease’ by Eissman et al. (https://doi.org/10.1093/brain/awac177).

Publication types

Editorial
Comment

MeSH terms

Alzheimer Disease* / pathology
Amyloid / genetics
Amyloidogenic Proteins
Amyloidosis*
Cognition
Female
Humans
Male
Sex Characteristics

Substances

Amyloid
Amyloidogenic Proteins