Brain death in children: is computed tomography angiography reliable as an ancillary test?

Background: The diagnosis of brain death is primarily clinical. Sometimes ancillary tests are needed.

Objective: This study compared sensitivity and interobserver agreement of the 10-, 7- and 4-point CT angiography scoring systems for the diagnosis of brain death in children.

Materials and methods: CT angiography examinations of 50 pediatric patients with a clinical diagnosis of brain death were evaluated according to 10-, 7- and 4-point scoring systems. Images were evaluated by two radiologists who considered the vessel opacification first in the arterial phase (A₀-V₅₀) and then in the venous phase (A₀-V₅₀). We evaluated interobserver agreement for the assessment of vessel opacification and diagnosis of brain death. We compared the differences among brain death diagnoses between children with craniotomy-craniectomy defects, open fontanelles and preserved bone integrity. We subdivided children into two groups according to age: ≤ 2 years and > 2 years. We calculated sensitivities according to age groups.

Results: Using the clinical exam as the reference standard, we found sensitivities for 10-, 7- and 4-point scoring systems to be 70%, 88% and 92% in the A₀-V₅₀ method and 40%, 82% and 82% in the A₅₀-V₅₀ method, respectively. Percentage agreement between readers was 78% for the 7-point scale using the A₀-V₅₀ method and more than 90% for other scoring systems for both the A₀-V₅₀ method and the A₅₀-V₅₀ method. The sensitivity was much lower in children with open anterior fontanelles compared to the groups with preserved bone integrity and with a craniotomy-craniectomy defect.

Conclusion: Just as in adult age groups, in children the 4-point scale appears to be more sensitive than the 10- and 7-point scales for CT angiography-based assessment of brain death. Because the scoring systems have similar sensitivities, they could be used as ancillary tests in pediatric cases.