Sudden Onset of IgA Vasculitis Affecting Vital Organs in Adult Patients following SARS-CoV-2 Vaccines

Yunjung Choi; Chang Hun Lee; Kyoung Min Kim; Wan-Hee Yoo

doi:10.3390/vaccines10060923

Sudden Onset of IgA Vasculitis Affecting Vital Organs in Adult Patients following SARS-CoV-2 Vaccines

Vaccines (Basel). 2022 Jun 9;10(6):923. doi: 10.3390/vaccines10060923.

Authors

Yunjung Choi^{1

2}, Chang Hun Lee^{2

3}, Kyoung Min Kim^{2

4}, Wan-Hee Yoo^{1

2}

Affiliations

¹ Division of Rheumatology, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju City 54907, Korea.
² Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju City 54907, Korea.
³ Division of Gastroenterology, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju City 54907, Korea.
⁴ Department of Pathology, Jeonbuk National University Medical School, Jeonju City 54907, Korea.

Abstract

IgA vasculitis is an immune complex-mediated small-vessel vasculitis that mainly occurs in children and is characterized by palpable purpura, arthralgia, abdominal pain, and glomerulonephritis. We report three cases of new-onset IgA vasculitis involving major organs in adult patients after they received either the ChAdOx1 viral vector (Oxford/AstraZeneca) vaccine or the messenger RNA-1273 (Moderna) vaccine. These cases suggest that COVID-19 vaccines have the potential to trigger IgA vasculitis and indicate that physicians need to monitor for this possible complication.

Keywords: COVID-19; ChAdOx1; IgA vasculitis; mRNA-1273; vaccination.

Publication types

Case Reports

Abstract

Publication types

Grants and funding