Curcuma zedoaria 50% methanol extracts increase adiponectin secretion by enhancing PPARγ mRNA expression in 3T3-L1 cells

Biosci Biotechnol Biochem. 2022 Aug 24;86(9):1295-1299. doi: 10.1093/bbb/zbac098.

Abstract

Curcuma zedoaria is a characteristic species of its genus that contains little to no curcuminoid. Here, we demonstrate that C. zedoaria extracts with 50% methanol increases adiponectin secretion into the media by enhancing PPARγ mRNA expression in 3T3-L1 cells. These results indicate that C. zedoaria may be useful for preventing/improving lifestyle-related diseases such as diabetes and atherosclerosis.

Keywords: Curcuma zedoaria; 3T3-L1 cells; lifestyle-related diseases.

MeSH terms

  • 3T3-L1 Cells
  • Adiponectin* / metabolism
  • Animals
  • Curcuma* / chemistry
  • Methanol
  • Mice
  • PPAR gamma* / genetics
  • Plant Extracts* / pharmacology
  • RNA, Messenger / genetics

Substances

  • Adiponectin
  • PPAR gamma
  • Plant Extracts
  • RNA, Messenger
  • Methanol