Abstract
A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer's disease. One of the isomers prepared was evaluated for its anticholinesterase activity in vivo, acute toxicity, and some behavioral effects. This compound was a competitive inhibitor of the enzyme and was found to antagonize the stimulating effect produced by scopolamine on locomotor activity and to facilitate memory consolidation.
MeSH terms
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Acetylcholinesterase / blood
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Acetylcholinesterase / metabolism*
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Animals
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Avoidance Learning / drug effects
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Behavior, Animal / drug effects*
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Brain / drug effects
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Brain / enzymology*
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Cerebral Cortex / drug effects
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Cerebral Cortex / physiology
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Exploratory Behavior / drug effects
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Kinetics
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Male
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Mice
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Mice, Inbred DBA
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Physostigmine / analogs & derivatives*
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Physostigmine / pharmacology
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Physostigmine / toxicity
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Rats
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Rats, Inbred Strains
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Reaction Time / drug effects
Substances
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physostigmine heptyl
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Physostigmine
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Acetylcholinesterase