DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature

Cureus. 2022 May 23;14(5):e25263. doi: 10.7759/cureus.25263. eCollection 2022 May.

Abstract

The mesentery constitutes a common location for the metastatic spread of malignant gastrointestinal tumors. Primary mesenteric tumors, on the other hand, are very rare; lymphomas are the most common, followed by benign and malignant mesenchymal tumors. We present a case of a 43-year-old patient operated on for a primary mesenteric leiomyosarcoma with a positive immunostain for DOG1, despite having no KIT or PDGFRa mutations on molecular analysis. Moreover, we review the pertinent literature.

Keywords: dog1; gastrointestinal stromal tumor; immunohistochemistry; leiomyosarcoma; mesentery.

Publication types

  • Case Reports