Polyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome

Clin Infect Dis. 2023 Feb 8;76(3):531-534. doi: 10.1093/cid/ciac514.

Abstract

In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.

Keywords: HIV/AIDS; IRIS; histoplasmosis.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Acquired Immunodeficiency Syndrome* / complications
  • CD4-Positive T-Lymphocytes
  • HIV
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • Histoplasmosis*
  • Humans
  • Immune Reconstitution Inflammatory Syndrome*