Antispike monoclonal antibody treatment of 180 B-cell-depleted patients with mild-to-moderate coronavirus disease 2019 (COVID-19) resulted in good outcomes overall, with only 12.2% progressing to severe disease, 9.4% requiring hospitalization, 0.6% requiring mechanical ventilation, no deaths within 30 days, and 1.8% developing persistent COVID-19. Antispike monoclonal antibodies appear effective in this immunocompromised population.
Keywords: COVID-19; SARS-CoV-2; anti-CD20; monoclonal antibody; rituximab.
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.