Strategic targeting of the temporal lobe with orthogonal placement of responsive neurostimulation leads

Responsive neurostimulation (RNS) is an effective treatment modality for refractory temporal lobe epilepsy (TLE). However, the optimal placement of RNS leads is not known. We use an orthogonal approach to lead placement instead of the more common longitudinal approach to target the entorhinal cortex (EC), given its potential for modulating activity entering and leaving the hippocampus. An orthogonal approach allows for coverage of the EC as well as the anterior lateral temporal cortex, which may be particularly beneficial for patients with mesial-lateral TLE and may also enable greater modulation of the limbic network. The objective of this study was to determine treatment outcomes for orthogonally placed RNS depth leads targeting the EC. We performed a retrospective analysis of prospectively collected data on a cohort of 13 patients. Mean follow-up duration was 57.3 months, and the 50% responder rate was 76.9%. These results show that orthogonally placed RNS leads are safe and effective for the treatment of refractory TLE. Larger cohorts are needed to further delineate the clinical utility of this novel targeting strategy.