Chronic active antibody-mediated rejection (caAMR) caused by de novo donor-specific antibodies (dnDSA) is the main risk factor of late allograft loss in kidney transplantation. The treatment remains difficult due to the lack of effective methods. Through comprehensive management pre and post kidney transplantation, which starts from the prevention of dnDSA generation, periodical monitoring of dnDSA, to timely implement of pathological diagnosis and early initiation of synthetical treatment, it will be beneficial to the prevention and treatment of caAMR and ultimately improve the long-term survival of the renal graft.
新生供者特异性抗体（dnDSA）介导的慢性活动性抗体介导排斥反应（caAMR）是引起后期移植肾功能丢失的主要原因，因缺乏特效手段而治疗棘手。通过肾移植全程管理，从预防dnDSA的产生、计划性监测dnDSA变化、及时明确病理诊断和尽早启动综合治疗着手，将有利于caAMR的防治和最终提高移植肾的长期存活率。.