Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma in Female Smokers and Never Smokers

Cancer Res. 2022 Sep 2;82(17):3116-3129. doi: 10.1158/0008-5472.CAN-21-3836.

Abstract

Single-cell analysis of healthy lung tissue and lung cancer reveals distinct tumor cell populations, including cells with differential immune modulating capacity between smokers and never smokers, which could guide future therapeutic strategies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma of Lung*
  • Adenocarcinoma* / pathology
  • Female
  • Humans
  • Lung Neoplasms* / pathology
  • Smokers
  • Smoking / adverse effects