Autophagosomal components recycling on autolysosomes

Yufen Wang; Huilin Que; Yueguang Rong

doi:10.1016/j.tcb.2022.06.012

Autophagosomal components recycling on autolysosomes

Trends Cell Biol. 2022 Nov;32(11):897-899. doi: 10.1016/j.tcb.2022.06.012. Epub 2022 Jul 12.

Authors

Yufen Wang¹, Huilin Que¹, Yueguang Rong²

Affiliations

¹ School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cell Architecture Research Center, Huazhong University of Science and Technology, Wuhan, China.
² School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cell Architecture Research Center, Huazhong University of Science and Technology, Wuhan, China. Electronic address: [email protected].

PMID: 35840484
DOI: 10.1016/j.tcb.2022.06.012

Abstract

Autophagy is a multistage, intracellular process. Here, we highlight a recently identified autophagosomal components recycling (ACR) stage and the recycler complex (SNX4-SNX5-SNX17), which mediates recycling of autophagosomal outer membrane proteins on the autolysosome surface immediately following autophagosome-lysosome fusion. This discovery opens numerous research directions into the postfusion fate of autophagosomes.

Keywords: ATG9A; STX17; autophagosomal components recycling; autophagy; lysosome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autophagosomes* / metabolism
Autophagy
Autophagy-Related Proteins / metabolism
Humans
Lysosomes* / metabolism
Membrane Fusion
Qa-SNARE Proteins / metabolism

Substances

Autophagy-Related Proteins
Qa-SNARE Proteins