PUVA-induced pigmented macules: a case involving palmoplantar skin

J Am Acad Dermatol. 1987 May;16(5 Pt 2):1087-90. doi: 10.1016/s0190-9622(87)70140-6.

Abstract

A patient with palmoplantar psoriasis received a local treatment regimen of psoralens with long-wave ultraviolet A radiation (PUVA). After approximately 12 months of treatment, she developed hyperpigmented macules on her palms and soles. A biopsy showed changes consistent with PUVA-induced pigmented macules, as well as pronounced pigmentary incontinence. No cytologic atypia was noted. PUVA-induced pigmented macules should now be included in the differential diagnosis of palmoplantar hyperpigmented macules.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Foot Dermatoses / etiology
  • Foot Dermatoses / pathology
  • Hand Dermatoses / etiology
  • Hand Dermatoses / pathology
  • Humans
  • Middle Aged
  • PUVA Therapy / adverse effects*
  • Pigmentation Disorders / etiology*
  • Pigmentation Disorders / pathology
  • Skin / pathology