Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?

Aging Dis. 2022 Jul 11;13(4):1005-1014. doi: 10.14336/AD.2022.0117.

Abstract

Acarbose can extend the life span of mice through a process involving the gut microbiota. Several factors affect the life span, including mitochondrial function, cellular senescence, telomere length, immune function, and expression of longevity-related genes. In this review, the effects of acarbose-regulated gut microbiota on the life span-influencing factors have been discussed. In addition, a novel theoretical basis for improving our understanding of the mechanisms by which acarbose extends the life span of mice has been suggested.

Keywords: acarbose; gut microbiota; life span.