Mosaic loss of Y chromosome during aging

Science. 2022 Jul 15;377(6603):266-267. doi: 10.1126/science.add0839. Epub 2022 Jul 14.

Authors

Andreas Zeiher^{1

2}, Thomas Braun^{2

3}

Affiliations

¹ Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.
² German Center for Cardiovascular Research DZHK, Partner Site Rhine-Main, Berlin, Germany.
³ Max Planck Institute for Heart and Lung Research, Department of Cardiac Development and Remodeling, Bad Nauheim, Germany.

PMID: 35857599
DOI: 10.1126/science.add0839

Abstract

Spread of Y chromosome aneuploidy in myeloid cells with age promotes cardiac fibrosis.

Publication types

Comment

MeSH terms

Aging* / genetics
Aneuploidy
Chromosome Deletion*
Chromosomes, Human, Y* / genetics
Fibrosis
Heart Diseases* / genetics
Humans
Male
Mosaicism*
Myocardium* / pathology