Unusual presentation of familial Mediterranean fever with co-existing polyarteritis nodosa and acute post-streptococcal glomerulonephritis

Yeşim Özdemir Atikel; Betül Emine Derinkuyu; Sevcan A Bakkaloğlu

doi:10.1002/ccr3.6022

Unusual presentation of familial Mediterranean fever with co-existing polyarteritis nodosa and acute post-streptococcal glomerulonephritis

Clin Case Rep. 2022 Jul 22;10(7):e6022. doi: 10.1002/ccr3.6022. eCollection 2022 Jul.

Authors

Yeşim Özdemir Atikel¹, Betül Emine Derinkuyu², Sevcan A Bakkaloğlu^{1

3}

Affiliations

¹ Department of Pediatric Nephrology Gazi University Faculty of Medicine Ankara Turkey.
² Department of Pediatric Radiology Gazi University Faculty of Medicine Ankara Turkey.
³ Department of Pediatric Rheumatology Gazi University Faculty of Medicine Ankara Turkey.

Abstract

Acute post-streptococcal glomerulonephritis (APSGN) and polyarteritis nodosa (PAN) may occur simultaneously after streptococcal infection in a child who is previously healthy but carries a Mediterranean fever (MEFV) mutation. The homozygous M694V mutation in the MEFV gene may cause an augmented response to the streptococcal infection that plays a role in the development of both clinical manifestations.

Keywords: case report; familial Mediterranean fever; polyarteritis nodosa; post‐streptococcal acute glomerulonephritis.

Publication types

Case Reports