Bilateral anterior and intermediate uveitis in SARS-CoV-2 associated multisystem inflammatory syndrome in a pediatric patient

Jessica Shantha; Amit K Reddy; Amol Sura; Adrian Tsang; Kareem Moussa; Nisha Acharya; John Gonzales; Thuy Doan

doi:10.1186/s12969-022-00712-8

Bilateral anterior and intermediate uveitis in SARS-CoV-2 associated multisystem inflammatory syndrome in a pediatric patient

Pediatr Rheumatol Online J. 2022 Jul 30;20(1):59. doi: 10.1186/s12969-022-00712-8.

Authors

Jessica Shantha¹, Amit K Reddy², Amol Sura³, Adrian Tsang⁴, Kareem Moussa⁵, Nisha Acharya⁴, John Gonzales⁴, Thuy Doan⁴

Affiliations

¹ Francis I. Proctor Foundation, Department of Ophthalmology, University of California San Francisco, 490 Illinois Street, CA, 94158, San Francisco, USA. [email protected].
² Department of Ophthalmology, University of Colorado School of Medicine, 1675 North Aurora Court F731, CO, 80045, Aurora, USA.
³ Department of Ophthalmology, Duke University, 2351 Erwin Rd, NC, 27705- 4699, Durham, USA.
⁴ Francis I. Proctor Foundation, Department of Ophthalmology, University of California San Francisco, 490 Illinois Street, CA, 94158, San Francisco, USA.
⁵ Davis Department of Ophthalmology & Vision Science, University of California, 4860 Y Street, Suite 2400, 490 Illinois Street, Floor 2, CA, 95817, 94158, Sacramento, San Francisco, USA.

Abstract

Purpose: To report a case of bilateral anterior intermediate uveitis after recovery from SARS-CoV-2 associated multisystem inflammatory syndrome in children (MIS-C).

Case report: A 9-year-old male presented with bilateral anterior intermediate uveitis with fluorescein angiography (FA) leakage of the disc and peripheral vasculature 1 month after recovery from MIS-C. He was treated with difluprednate 0.05% in both eyes with resolution of FA leakage, but our patient has required an extended treatment of topical therapy and the need long term immunosuppression.

Conclusions: This is a case of uveitis presenting after recent MIS-C related to SARS-CoV-2. Ongoing follow up and monitoring is required, and it is important for the ophthalmologist and rheumatologist to be aware of this rare complication during the current COVID-19 pandemic.

Keywords: COVID-19; Multisystem inflammatory syndrome in children; Uveitis.

Publication types

Case Reports

MeSH terms

COVID-19* / complications
Child
Humans
Male
Pandemics
SARS-CoV-2
Systemic Inflammatory Response Syndrome
Uveitis*
Uveitis, Intermediate*

Supplementary concepts

pediatric multisystem inflammatory disease, COVID-19 related

Grants and funding

K-23EY030159/EY/NEI NIH HHS/United States