Eye movements as a measure of word comprehension deficits in primary progressive aphasia

Brain Lang. 2022 Sep:232:105165. doi: 10.1016/j.bandl.2022.105165. Epub 2022 Jul 28.

Abstract

Introduction: Eye movement studies can uncover subtle aspects of language processing impairment in individuals with primary progressive aphasia (PPA), who may have difficulty understanding words. This study examined eye movement patterns on a word-object matching task in response to varying levels of word-knowledge in PPA.

Methods: Participants with semantic and non-semantic PPA completed an object-matching task, where a word was presented and participants then selected the corresponding pictured object from an array. Afterwards, participants defined words for trials to which they incorrectly pointed. Linear mixed-effects analyses examined fixation differences on targets and related and unrelated foils.

Results: On incorrectly-pointed trials, participants demonstrated greater fixation duration on related foils, demonstrating intra-category blurring. For words that could not be defined, there was similar fixation duration on related and unrelated foils, demonstrating inter-category semantic blurring.

Discussion: This study demonstrated that fixation patterns reflect varying levels of word knowledge in PPA.

Keywords: Eye Movement; Primary Progressive Aphasia; Word Comprehension.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aphasia, Primary Progressive*
  • Comprehension / physiology
  • Eye Movements*
  • Humans
  • Neuropsychological Tests
  • Semantics