Necroptosis pathways in tumorigenesis

Semin Cancer Biol. 2022 Nov;86(Pt 3):32-40. doi: 10.1016/j.semcancer.2022.07.007. Epub 2022 Jul 28.

Abstract

Necroptosis is a caspase-independent form of programmed cell death executed by the receptor interacting protein kinase 1 (RIPK1)-RIPK3-mixed lineage kinase domain-like protein (MLKL) signaling cascade, deregulation of which can cause various human diseases including cancer. Escape from programmed cell death is a hallmark of cancer, leading to uncontrolled growth and drug resistance. Therefore, it is crucial to further understand whether necroptosis plays a key role in therapeutic resistance. In this review, we summarize the recent findings of the link between necroptosis and cancer, and discuss that targeting necroptosis is a new strategy to overcome apoptosis resistance in tumor therapy.

Keywords: Inflammation; Necroptosis; RIPK1; RIPK3; Tumorigenesis.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Apoptosis / genetics
  • Carcinogenesis / genetics
  • Humans
  • Necroptosis* / genetics
  • Protein Kinases*
  • Signal Transduction

Substances

  • Protein Kinases