Glioma is a common malignant tumor with a high incidence rate but a low cure rate. In this paper, one previously undescribed limonoid (1), along with two known cipadesin-type limonoids 2 and 3, were isolated from Cipadessa baccifera. Their structures were established based on a comprehensive analysis of NMR and MS spectra. Compound 1 exhibited moderate cytotoxicity against U251 and BT-325 cells with IC50 values of 7.32 ± 0.21 and 13.25 ± 0.35 μM, suggesting that 1 might be a promising leading compound for the treatment of glioma.
Keywords: Cipadessa baccifera (Roth) Miq.; U251; cytotoxicity.