Decrease in CD8+CD45+CCR7+CD62L+ T cells in individuals vaccinated with Sinovac-CoronaVac following COVID-19 infection

Dâmaris C S C Fonseca; Mirtes C B Rocha; Lucca A Pereira; Leticia P Botega; Susanne C P F Cutrim; Fabiano V Silva; Flávio D Batista; Adriana S Rêgo; Ângela Falcai; Lídio G Lima-Neto; Ana Paula S A Santos; Rafael C Carvalho; Eduardo M Sousa

doi:10.1016/j.clim.2022.109092

Decrease in CD8⁺CD45⁺CCR7⁺CD62L⁺ T cells in individuals vaccinated with Sinovac-CoronaVac following COVID-19 infection

Clin Immunol. 2022 Sep:242:109092. doi: 10.1016/j.clim.2022.109092. Epub 2022 Aug 6.

Affiliations

¹ Graduate Program in Microbial Biology, CEUMA University - UniCEUMA, São Luís, Brazil.
² Central Public Health Laboratory of Maranhão - LACEN-MA, São Luís, Brazil; Graduate Program in Health Sciences, Federal University of Maranhão - UFMA, São Luís, Brazil.
³ Central Public Health Laboratory of Maranhão - LACEN-MA, São Luís, Brazil; IOC/FIOCRUZ-RJ - Graduate Program in Tropical Medicine, Brazil.
⁴ Graduate Program in Health and Services Management, CEUMA University - UniCEUMA, São Luís, Brazil.
⁵ Graduate Program in Microbial Biology, CEUMA University - UniCEUMA, São Luís, Brazil; Central Public Health Laboratory of Maranhão - LACEN-MA, São Luís, Brazil.
⁶ Graduate Program in Health Sciences, Federal University of Maranhão - UFMA, São Luís, Brazil.
⁷ Graduate Program in Microbial Biology, CEUMA University - UniCEUMA, São Luís, Brazil; Graduate Program in Health and Services Management, CEUMA University - UniCEUMA, São Luís, Brazil. Electronic address: [email protected].

Abstract

Vaccines induce antibodies, but T cell responses are also important for protection against Coronavirus disease 2019. Here, we analyzed the frequency of memory T cells in infected and/or vaccinated individuals and observed a decrease in central memory T cells in individuals who were vaccinated following COVID-19 infection.

Keywords: COVID-19; Immune memory; T cells; Vaccination.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral
CD8-Positive T-Lymphocytes* / cytology
COVID-19 Vaccines* / immunology
COVID-19* / prevention & control
Humans
Memory T Cells / cytology
Vaccination

Substances

Antibodies, Viral
COVID-19 Vaccines