T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients

Savitree Thummasorn; Sopida Apichai; Supat Chupradit; Pornpen Sirisattayawong; Pachpilai Chaiwong; Sirawit Sriwichaiin; Wasana Pratchayasakul; Nipon Chattipakorn; Siriporn C Chattipakorn

doi:10.1371/journal.pone.0273327

T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients

PLoS One. 2022 Aug 19;17(8):e0273327. doi: 10.1371/journal.pone.0273327. eCollection 2022.

Authors

Affiliations

¹ Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
² Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
³ Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand.
⁴ Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.

Abstract

The cognitive impairment, depression, a decrease in the ability to perform activities of daily living (ADLs), and salivary gland dysfunction, as indicated by the reduction of alpha-amylase activity, have been reported in patients with type 2 diabetes (T2DM). However, the effects of depression on cognitive function, salivary alpha-amylase activity, and ADLs in T2DM patients have never been investigated. In this study, 115 participants were divided into three groups, including 30 healthy people, 50 T2DM patients without depression, and 35 T2DM patients with depression. Then, the cognitive function, the level of depression, salivary-alpha amylase activity, ADLs, and metabolic parameters were determined. Results showed that T2DM patients had hyperglycemia and cognitive impairment. A decrease in the salivary alpha-amylase activity was observed in T2DM patients. Interestingly, T2DM patients with depression had higher level of hyperglycemia and cognitive impairment than T2DM patients. Additionally, cognitive function was associated with the salivary-alpha amylase activity in T2DM without depression, while the severity of depression was associated with the salivary-alpha amylase activity in T2DM patients with depression. Therefore, we concluded that T2DM caused the impairment of metabolism, decreased salivary alpha-amylase activity, and cognitive impairment. Furthermore, T2DM patients with depression had higher level of hyperglycemia and cognitive decline than T2DM patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Activities of Daily Living
Cognitive Dysfunction* / complications
Depression / complications
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / metabolism
Humans
Hyperglycemia* / complications
Salivary alpha-Amylases*

Substances

Salivary alpha-Amylases

Grants and funding

This work was supported by the Faculty of Associated Medical Sciences from Chiang Mai University, Thailand (ST), the Senior Research Scholar grant from the National Research Council of Thailand (SCC); an NSTDA Research Chair Grant from the National Science and Technology Development Agency Thailand (NC) and a Chiang Mai University Excellence Center Award (NC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.