PYGBacking on glycogen metabolism to fuel early memory T cell recall responses

Joseph Longo; McLane J Watson; Matthew J Vos; Kelsey S Williams; Russell G Jones

doi:10.1016/j.molcel.2022.07.016

PYGBacking on glycogen metabolism to fuel early memory T cell recall responses

Mol Cell. 2022 Aug 18;82(16):2918-2921. doi: 10.1016/j.molcel.2022.07.016.

Authors

Joseph Longo¹, McLane J Watson¹, Matthew J Vos¹, Kelsey S Williams¹, Russell G Jones²

Affiliations

¹ Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
² Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA. Electronic address: [email protected].

Abstract

Zhang et al. (2022) show that TCR signaling promotes the phosphorylation and activation of glycogen phosphorylase B (PYGB) in CD8⁺ memory T (Tmem) cells. PYGB-dependent glycogen mobilization provides a carbon source to support glycolysis and early Tmem cell recall responses.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Comment

MeSH terms

Glycogen* / metabolism
Glycolysis
Memory T Cells*
Signal Transduction

Substances

Glycogen

Abstract

Publication types

MeSH terms

Substances

Grants and funding