AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models
Clin Transl Med
.
2022 Aug;12(8):e952.
doi: 10.1002/ctm2.952.
Authors
Sophia Millington-Ward
1
,
Naomi Chadderton
1
,
Laura K Finnegan
1
,
Iris J M Post
1
,
Matthew Carrigan
1
,
Tom Gardiner
2
,
Elisa Peixoto
2
,
Daniel Maloney
1
,
Marian M Humphries
1
,
Alan Stitt
2
,
Thierry Léveillard
3
,
Pete Humphries
1
,
Paul F Kenna
1
4
,
Arpad Palfi
1
,
G Jane Farrar
1
Affiliations
1
Smurfit Institute of Genetics, School of Genetics and Microbiology, Trinity College Dublin, Dublin 2, Ireland.
2
Queen's University Belfast, Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Belfast, UK.
3
Department of Genetics, Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.
4
Research Foundation, Royal Victoria Eye and Ear Hospital, Dublin 2, Ireland.
PMID:
35988157
PMCID:
PMC9393074
DOI:
10.1002/ctm2.952
No abstract available
Publication types
Letter
Research Support, Non-U.S. Gov't
MeSH terms
Dependovirus / genetics
Genetic Therapy*
Humans
Macular Degeneration* / genetics
Macular Degeneration* / therapy
Mitochondria / genetics
Grants and funding
MC_PC_19023/MRC_/Medical Research Council/United Kingdom