MR Imaging in Primary Sclerosing Cholangitis and Other Cholangitis

Ciara O'Brien; Mikail Malik; Kartik Jhaveri

doi:10.1016/j.rcl.2022.05.007

MR Imaging in Primary Sclerosing Cholangitis and Other Cholangitis

Radiol Clin North Am. 2022 Sep;60(5):843-856. doi: 10.1016/j.rcl.2022.05.007. Epub 2022 Jul 8.

Authors

Ciara O'Brien¹, Mikail Malik², Kartik Jhaveri³

Affiliations

¹ Department of Medical Imaging, JDMI University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.
² McMaster University, Hamilton, ON L8S 4L8, Canada.
³ Department of Medical Imaging, JDMI University Health Network, University of Toronto, 610 University Avenue, 3-957, Toronto, Ontario M5G 2M9, Canada. Electronic address: [email protected].

PMID: 35989048
DOI: 10.1016/j.rcl.2022.05.007

Abstract

Sclerosing cholangitis is characterized by irregular and ill-defined inflammation, fibrosis, and stricturing of the bile ducts and may be primary or secondary in cause. It causes progressive destruction of the biliary tree, progressive parenchymal cirrhosis, hepatic failure, and malignancy such as cholangiocarcinoma. The subtypes of sclerosing cholangitis can be broken down into primary sclerosing cholangitis (PSC), immune-mediated sclerosing cholangitis, infectious cholangitis, and ischemic cholangitis with other causes including metastatic disease and chemotherapy change. MR imaging is the gold standard test to investigate and differentiate PSC and other types of cholangitis.

Keywords: Cholangitis; MR imaging; Primary sclerosing cholangitis (PSC).

Publication types

Review

MeSH terms

Bile Duct Neoplasms*
Bile Ducts, Intrahepatic / pathology
Cholangiocarcinoma* / complications
Cholangiocarcinoma* / pathology
Cholangitis, Sclerosing* / complications
Cholangitis, Sclerosing* / diagnostic imaging
Fibrosis
Humans
Magnetic Resonance Imaging / adverse effects