Disrupting interaction between miR-132 and Mmp9 3'UTR improves synaptic plasticity and memory in mice

Bozena Kuzniewska; Karolina Rejmak; Agata Nowacka; Magdalena Ziółkowska; Jacek Milek; Marta Magnowska; Jakub Gruchota; Olga Gewartowska; Ewa Borsuk; Ahmad Salamian; Andrzej Dziembowski; Kasia Radwanska; Magdalena Dziembowska

doi:10.3389/fnmol.2022.924534

Disrupting interaction between miR-132 and Mmp9 3'UTR improves synaptic plasticity and memory in mice

Front Mol Neurosci. 2022 Aug 5:15:924534. doi: 10.3389/fnmol.2022.924534. eCollection 2022.

Affiliations

¹ Laboratory of Molecular Basis of Synaptic Plasticity, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
² Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland.
³ Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, Poland.
⁴ Faculty of Biology, University of Warsaw, Warsaw, Poland.

Abstract

As microRNAs have emerged to be important regulators of molecular events occurring at the synapses, the new questions about their regulatory effect on the behavior have araised. In the present study, we show for the first time that the dysregulated specific targeting of miR132 to Mmp9 mRNA in the mouse brain results in the increased level of Mmp9 protein, which affects synaptic plasticity and has an effect on memory formation. Our data points at the importance of complex and precise regulation of the Mmp9 level by miR132 in the brain.

Keywords: Mmp9; behavior; brain; miR132; microRNA; synaptic plasticity.