Serglycin-induced interleukin-1β from oesophageal cancer cells upregulate hepatocyte growth factor in fibroblasts to promote tumour angiogenesis and growth

Clin Transl Med. 2022 Aug;12(8):e1031. doi: 10.1002/ctm2.1031.

Authors

Dongdong Yan¹, Di Cui¹, Yun Zhu², Cecilia Ka Wing Chan³, Chung Hang Jonathan Choi³, Tengfei Liu¹, Sai Wah Tsao¹, Stephanie Ma^{1

4}, Annie Lai Man Cheung¹

Affiliations

¹ School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China.
² Center for Clinical Big Data and Analytics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
³ Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, SAR, China.
⁴ The University of Hong Kong - Shenzhen Hospital, Shenzhen, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Esophageal Neoplasms* / genetics
Esophageal Neoplasms* / metabolism
Fibroblasts / metabolism
Fibroblasts / pathology
Hepatocyte Growth Factor* / genetics
Hepatocyte Growth Factor* / metabolism
Humans
Interleukin-1beta / metabolism
Interleukin-1beta / pharmacology
Neovascularization, Pathologic / genetics
Neovascularization, Pathologic / metabolism
Neovascularization, Pathologic / pathology
Proteoglycans
Vesicular Transport Proteins

Substances

Interleukin-1beta
Proteoglycans
Vesicular Transport Proteins
serglycin
Hepatocyte Growth Factor