Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack

J Korean Med Sci. 2022 Aug 22;37(33):e254. doi: 10.3346/jkms.2022.37.e254.

Abstract

This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.

Keywords: Event Outcome; Ischemic Attack, Transient; Minor Ischemic Stroke; Stroke Recurrence.

MeSH terms

  • Atherosclerosis*
  • Humans
  • Ischemic Attack, Transient* / complications
  • Ischemic Attack, Transient* / diagnosis
  • Ischemic Attack, Transient* / epidemiology
  • Ischemic Stroke*
  • Recurrence
  • Risk Factors
  • Stroke* / diagnosis
  • Stroke* / epidemiology
  • Stroke* / etiology