CD39/CD73 dysregulation and adenosine metabolism contribute to T-cell immunosuppression in patients with Sézary syndrome

Blood. 2023 Jan 5;141(1):111-116. doi: 10.1182/blood.2022017259.

Authors

Affiliations

¹ Laboratory of Immunogenetics, Department of Medical Sciences, University of Turin, Turin, Italy.
² Pathology Unit, Department of Oncology, University of Turin, Turin, Italy.
³ Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.
⁴ Dermatologic Clinic, Department of Medical Sciences, University of Turin, Turin, Italy.

PMID: 36040496
DOI: 10.1182/blood.2022017259

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

5'-Nucleotidase* / metabolism
Adenosine / metabolism
Adenosine Triphosphate / metabolism
Apyrase* / metabolism
Humans
Immune Tolerance*
Immunosuppression Therapy*
Sezary Syndrome* / metabolism
Sezary Syndrome* / therapy
Skin Neoplasms* / metabolism
Skin Neoplasms* / therapy
T-Lymphocytes*

Substances

5'-Nucleotidase
Adenosine
Adenosine Triphosphate
Apyrase
ENTPD1 protein, human
NT5E protein, human