Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma

Esther E E Drees; Julia Driessen; Gerben J C Zwezerijnen; Sandra A W M Verkuijlen; Jakoba J Eertink; Monique A J van Eijndhoven; Nils J Groenewegen; Andrea Vallés-Martí; Daphne de Jong; Ronald Boellaard; Henrica C W de Vet; Dirk M Pegtel; Josée M Zijlstra

doi:10.1002/jha2.432

Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma

EJHaem. 2022 Apr 28;3(3):908-912. doi: 10.1002/jha2.432. eCollection 2022 Aug.

Authors

Esther E E Drees^{1

2}, Julia Driessen^{2

3}, Gerben J C Zwezerijnen^{2

4}, Sandra A W M Verkuijlen^{1

2}, Jakoba J Eertink^{2

5}, Monique A J van Eijndhoven^{1

2}, Nils J Groenewegen^{1

2

6}, Andrea Vallés-Martí^{1

2}, Daphne de Jong^{1

2}, Ronald Boellaard^{2

4}, Henrica C W de Vet^{2

7}, Dirk M Pegtel^{1

2

6}, Josée M Zijlstra^{1

5}

Affiliations

¹ Amsterdam UMC Location Vrije Universiteit Amsterdam Department of Pathology Boelelaan Amsterdam The Netherlands.
² Cancer Center Amsterdam Imaging and Biomarkers Amsterdam The Netherlands.
³ Amsterdam UMC location University of Amsterdam Department of Hematology LYMMCARE (Lymphoma and Myeloma Center) Meibergdreef Amsterdam The Netherlands.
⁴ Amsterdam UMC Location Vrije Universiteit Amsterdam Department of Radiology and Nuclear Medicine Boelelaan Amsterdam The Netherlands.
⁵ Amsterdam UMC Location Vrije Universiteit Amsterdam Department of Hematology Boelelaan Amsterdam The Netherlands.
⁶ Exbiome B.V. Amsterdam The Netherlands.
⁷ Amsterdam UMC Location Vrije Universiteit Amsterdam Department of Epidemiology and Data Science Amsterdam Public Health research institute Boelelaan Amsterdam The Netherlands.

Abstract

Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative ¹⁸F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.

Keywords: FDG‐PET; Hodgkin lymphoma; Radiomics; TARC; extracellular vesicles; miRNAs.