Exploring the human extraembryonic mesoderm using naive pluripotent stem cells

Takumi Okubo; Yasuhiro Takashima

doi:10.1016/j.stem.2022.08.005

Exploring the human extraembryonic mesoderm using naive pluripotent stem cells

Cell Stem Cell. 2022 Sep 1;29(9):1290-1291. doi: 10.1016/j.stem.2022.08.005.

Authors

Takumi Okubo¹, Yasuhiro Takashima²

Affiliations

¹ Department of Life Science Frontiers, CiRA, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
² Department of Life Science Frontiers, CiRA, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: [email protected].

PMID: 36055188
DOI: 10.1016/j.stem.2022.08.005

Abstract

In this issue of Cell Stem Cell, Pham et al. report that naive human pluripotent stem cells can be differentiated into extraembryonic mesoderm cells (EXMCs). EXMCs are maintained for up to 70 days, resemble human and monkey extraembryonic mesoderm, and provide a model to study EXMC specification and function.

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MeSH terms

Cell Differentiation
Humans
Mesoderm*
Pluripotent Stem Cells*