Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain. This provides new opportunities to understand human brain development and neurological disorders.
Keywords: Astroglia; Chimera; Human pluripotent stem cells; Macroglia; Microglia; Neurological Disorders; Neurons; Oligodendroglia.
© 2022. The Author(s).