Pulmonary calcinosis associated with Alport syndrome

Valentine Mismetti; Marie-Pierre Perquis; Lina Hamdi; Marios E Froudarakis; Jean-Michel Vergnon

doi:10.1016/j.rmcr.2022.101727

Pulmonary calcinosis associated with Alport syndrome

Respir Med Case Rep. 2022 Aug 24:39:101727. doi: 10.1016/j.rmcr.2022.101727. eCollection 2022.

Authors

Valentine Mismetti¹, Marie-Pierre Perquis¹, Lina Hamdi¹, Marios E Froudarakis¹, Jean-Michel Vergnon¹

Affiliation

¹ Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, France.

Abstract

We report the case of a 48-year-old woman under dialysis from chronic renal failure (CRF) since the age of 27, due to Alport syndrome. The patient underwent routine chest X-ray on which diffuse micronodules were shown. Chest computed tomography showed partially calcified micronodules with centrilobular distribution respecting the subpleural spaces and predominant in the upper lobar regions. Metastatic pulmonary calcinosis was confirmed by the bone scan with an overall course of 29 years. This is the first reported case of pulmonary calcinosis from CRF due to Alport syndrome.

Keywords: Alport syndrome; Bone scan; Pulmonary calcinosis; Renal failure.

Publication types

Case Reports