Abstract
This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.
©2022 American Association for Cancer Research.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line
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Colorectal Neoplasms* / genetics
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Colorectal Neoplasms* / metabolism
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Cyclic AMP Response Element-Binding Protein / genetics
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Cyclic AMP Response Element-Binding Protein / metabolism
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Cyclic AMP-Dependent Protein Kinases / genetics
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Cyclic AMP-Dependent Protein Kinases / metabolism
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Humans
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Neoplasm Metastasis / genetics
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Neoplasm Metastasis / physiopathology
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Neoplastic Stem Cells* / metabolism
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Signal Transduction
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Smad4 Protein / genetics
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Smad4 Protein / metabolism
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Transforming Growth Factor beta / genetics
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Transforming Growth Factor beta / metabolism
Substances
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Cyclic AMP Response Element-Binding Protein
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Cyclic AMP-Dependent Protein Kinases
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Smad4 Protein
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SMAD4 protein, human
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Transforming Growth Factor beta
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CREB1 protein, human