A Supramolecular Approach to Antimicrobial Surfaces

Molecules. 2022 Sep 5;27(17):5731. doi: 10.3390/molecules27175731.

Abstract

In this paper, we report on the preparation of Imidazole-functionalized glass surfaces, demonstrating the ability of a dinuclear Cu(II) complex of a macrocyclic ligand to give a "cascade" interaction with the deprotonated forms of grafted imidazole moieties. In this way, we realized a prototypal example of an antimicrobial surface based on a supramolecular approach, obtaining a neat microbicidal effect using low amounts of the described copper complex.

Keywords: antibacterial surfaces; cascade complexes; copper complexes; microbicidal effect; self-assembled monolayers; supramolecular complex; surface functionalization.

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Copper*
  • Glass
  • Imidazoles / pharmacology
  • Ligands

Substances

  • Anti-Bacterial Agents
  • Imidazoles
  • Ligands
  • Copper

Grants and funding

This research was funded by University of Pavia, Fondo Ricerca Giovani 2019.