Battle of the γδ T cell subsets in the gut

Sofia Mensurado; Bruno Silva-Santos

doi:10.1016/j.trecan.2022.08.006

Battle of the γδ T cell subsets in the gut

Trends Cancer. 2022 Nov;8(11):881-883. doi: 10.1016/j.trecan.2022.08.006. Epub 2022 Sep 8.

Authors

Sofia Mensurado¹, Bruno Silva-Santos²

Affiliations

¹ Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
² Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. Electronic address: [email protected].

PMID: 36088250
DOI: 10.1016/j.trecan.2022.08.006

Abstract

In a study in Science, Reis et al. describe a temporal segregation of γδ T cell activities in colorectal cancer (CRC). Initially tumor surveillance is orchestrated by interferon-γ (IFN-γ)-producing and cytotoxic γδ T cell subsets, but once the tumor thrives, it becomes infiltrated by interleukin (IL)-17⁺ γδ T cell subsets that promote its growth.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Interferon-gamma
Neoplasms*
Receptors, Antigen, T-Cell, gamma-delta*
T-Lymphocyte Subsets

Substances

Receptors, Antigen, T-Cell, gamma-delta
Interferon-gamma