mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2

Yuxuan Han; Yaling An; Qian Chen; Kun Xu; Xueyuan Liu; Senyu Xu; Huixin Duan; Annette B Vogel; Uğur Şahin; Qihui Wang; Lianpan Dai; George F Gao

doi:10.1038/s41422-022-00720-z

mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2

Cell Res. 2022 Nov;32(11):1022-1025. doi: 10.1038/s41422-022-00720-z. Epub 2022 Sep 14.

Authors

Yuxuan Han^#¹, Yaling An^#¹, Qian Chen^#^{2

3}, Kun Xu^#^{4

5}, Xueyuan Liu^#⁶, Senyu Xu⁴, Huixin Duan¹, Annette B Vogel⁷, Uğur Şahin⁷, Qihui Wang^{8

9}, Lianpan Dai^{10

11

12}, George F Gao^{13

14

15}

Affiliations

¹ Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
² Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui, China.
³ CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
⁴ Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
⁵ Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
⁶ School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
⁷ BioNTech SE, Mainz, Germany.
⁸ Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China. [email protected].
⁹ CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. [email protected].
¹⁰ Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China. [email protected].
¹¹ CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. [email protected].
¹² Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China. [email protected].
¹³ Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China. [email protected].
¹⁴ CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. [email protected].
¹⁵ Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
COVID-19* / prevention & control
Humans
SARS-CoV-2*
Spike Glycoprotein, Coronavirus / genetics
Vaccines, Synthetic
mRNA Vaccines

Substances

mRNA Vaccines
Vaccines, Synthetic
Antibodies, Viral
Antibodies, Neutralizing
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2